Recently, researchers from China Medical University Taiwan discovered a common use of sodium benzoate as a food preservative in the treatment of schizophrenia. Recently published in Biological Psychiatry entitled "Sodium Benzoate, a D-Amino Acid Oxidase Inhibitor, Added to Clozapine for the Treatment of Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Trial [Sodium Benzoate , A D-amino acid oxidase inhibitor combined with clozapine in the treatment of schizophrenia: a randomized, placebo-controlled, double-blind clinical study] article shows that sodium benzoate is refractory to clozapine resistance The symptoms of the disease are effectively improved in the group of patients with schizophrenia.
Regarding the results of the study, John Krystal, MD, editor of Biological Neurology and professor at Yale University School of Medicine, pointed out that D-serine receptors are a long-standing therapeutic target in the development of schizophrenia drugs over the years. Sodium benzoate is probably the first meaningful tool we have to actively influence this target.
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